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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPK12
All Species:
43.33
Human Site:
Y135
Identified Species:
79.44
UniProt:
P53778
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53778
NP_002960.2
367
41940
Y135
D
R
I
Q
F
L
V
Y
Q
M
L
K
G
L
R
Chimpanzee
Pan troglodytes
Q95NE7
360
41475
Y132
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Rhesus Macaque
Macaca mulatta
XP_001112462
367
41940
Y135
D
R
I
Q
F
L
V
Y
Q
M
L
K
G
L
R
Dog
Lupus familis
XP_848658
287
32890
E83
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
Cat
Felis silvestris
Mouse
Mus musculus
O08911
367
42025
Y135
D
R
I
Q
F
L
V
Y
Q
M
L
K
G
L
K
Rat
Rattus norvegicus
Q63538
367
41967
Y135
D
R
I
Q
F
L
V
Y
Q
M
L
K
G
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509537
374
42522
Y132
D
K
I
Q
Y
L
V
Y
Q
M
L
K
G
L
K
Chicken
Gallus gallus
XP_001233062
310
36087
A106
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
Frog
Xenopus laevis
P47812
361
41700
Y133
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Zebra Danio
Brachydanio rerio
O42376
363
41952
Y133
E
R
V
Q
Y
L
V
Y
Q
M
L
K
G
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61443
365
42080
Y135
D
H
V
Q
F
L
V
Y
Q
I
L
R
G
L
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17446
377
43900
Y143
D
H
I
Q
F
L
V
Y
Q
I
L
R
G
L
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q96TL5
358
41225
Y123
Q
F
I
Q
Y
F
L
Y
Q
I
M
R
G
L
K
Conservation
Percent
Protein Identity:
100
61.8
99.1
74.1
N.A.
92.6
93.7
N.A.
66.5
65.4
60.2
67.8
N.A.
56.9
N.A.
54.6
N.A.
Protein Similarity:
100
77.6
99.1
75.7
N.A.
95.9
96.1
N.A.
77.5
76.5
76.5
81.7
N.A.
73.8
N.A.
72.1
N.A.
P-Site Identity:
100
60
100
0
N.A.
93.3
93.3
N.A.
80
6.6
60
73.3
N.A.
66.6
N.A.
73.3
N.A.
P-Site Similarity:
100
93.3
100
13.3
N.A.
100
100
N.A.
100
13.3
93.3
100
N.A.
93.3
N.A.
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
46.5
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
65.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
40
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
80
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% C
% Asp:
77
0
0
0
0
0
0
0
8
0
0
8
0
0
0
% D
% Glu:
8
0
0
0
0
0
0
8
0
0
16
0
0
8
0
% E
% Phe:
0
8
0
0
62
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
8
0
0
0
0
0
0
0
85
0
0
% G
% His:
0
31
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
54
0
0
0
16
0
0
39
0
0
0
8
0
% I
% Lys:
0
8
8
0
0
0
0
0
0
0
0
47
8
0
70
% K
% Leu:
0
8
0
8
0
77
16
0
0
0
77
8
0
85
16
% L
% Met:
0
0
0
0
0
0
0
0
0
47
8
0
0
0
0
% M
% Asn:
0
0
8
0
0
8
8
0
0
8
0
0
0
0
0
% N
% Pro:
8
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
85
0
0
0
0
85
0
0
0
0
0
0
% Q
% Arg:
0
39
0
0
0
0
0
0
0
0
0
39
0
0
16
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
31
0
0
8
62
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
24
0
0
85
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _